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HRID1348641

反应详情

EQUATION

反应方程式

HRID 1348641 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(Oc1ccc(F)cc1[N+](=O)[O-])C(C(=O)O)N(Cc1ccccc1)Cc1ccccc1
HCID21091402

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(Oc1ccc(F)cc1N)C(C(=O)O)N(Cc1ccccc1)Cc1ccccc1
HCID21091420

未命名化合物

收率 96.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Ni]
催化剂HCID935

Nickel

Ni

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

0.10 g (0.22 mmol) 2-dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-3-methyl-butyric acid in 3.4 ml methanol were hydrogenated with 0.03 g Raney-Nickel. Filtration and removal of the solvent by distillation yielded 0.09 g (93%) 3-(2-amino-4-fluoro-phenoxy)-2-dibenzylamino-3-methyl-butyric acid as colorless solid, MS m/e (%): 423.3 (M+H+, 100).

WORKUP

后处理

  1. filtrationFiltration and removal of the solvent
  2. distillationby distillation