HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-3-methyl-butyric acid → 3-(2-Amino-4-fluoro-phenoxy)-2-dibenzylamino-3-methyl-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-3-methyl-butyric acid | HCID 21091402 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2-Amino-4-fluoro-phenoxy)-2-dibenzylamino-3-methyl-butyric acid | HCID 21091420 | 96.8% |
Reaction Steps
0.10 g (0.22 mmol) 2-dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-3-methyl-butyric acid in 3.4 ml methanol were hydrogenated with 0.03 g Raney-Nickel. Filtration and removal of the solvent by distillation yielded 0.09 g (93%) 3-(2-amino-4-fluoro-phenoxy)-2-dibenzylamino-3-methyl-butyric acid as colorless solid, MS m/e (%): 423.3 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211573B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-2c671c2e387442ef945d9b7f9e16ebf5 |
| Source note | uspto-grants-2007_05 |