Phosphoric Acid → HCID 67076825, compound

HRID 1348647Notes

Reaction equation

HRID 1348647 reaction equation
C(OC(=O)[NH:7][C@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[O:10][C@H:9]1[CH2:20][CH3:21])(C)(C)C.P(=O)(O)(O)O>O1CCCC1>[NH2:7][C@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[O:10][C@H:9]1[CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 67076893HCID 67076893, compound

Product 1

HCID 67076825HCID 67076825, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in quantitative yield by reaction of 590 mg (1.93 mmol) ((6S,7R)-6-ethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl)-carbamic acid tert-butyl ester with 2.86 g (29 mmol) ortho phosphoric acid in 6 ml tetrahydrofurane, MS m/e (%): 207.1 (M+H+, 100).

Sources & evidence

ORD record
ord-a665b22c8db6464ab7f451527749049e
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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