Trifluoroacetic acid → HCID 21091439, compound

HRID 1348652Notes

Reaction equation

HRID 1348652 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([F:20])([F:19])[F:18])[C:12]2[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:11]=2[O:10][C@@H:9]1[CH3:26])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([F:18])([F:20])[F:19])[C:12]2[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:11]=2[O:10][C@@H:9]1[CH3:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67077130[(6R,7S)-2-fluoro-6-methyl-8-oxo-9-(2,2,2-trifluoro-ethyl)-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester

Product 1

HCID 21091439HCID 21091439, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared in 75% yield by reaction of 3.70 g (9.0 mmol) [(6R,7S)-2-fluoro-6-methyl-8-oxo-9-(2,2,2-trifluoro-ethyl)-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester with 18 ml trifluoroacetic acid in 75 ml dichloromethane, MS m/e (%): 293.1 (M+H+, 100).

Sources & evidence

ORD record
ord-da2727d737464395b9e8d8d36d173068
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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