Triethylamine → HCID 18533223, compound

HRID 1348679Notes

Reaction equation

HRID 1348679 reaction equation
[S:1](Cl)(Cl)(=[O:3])=[O:2].[OH:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:8]=1[NH:14][S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16].C(N(CC)CC)C>C(Cl)Cl>[CH3:13][C:11]1[CH:10]=[CH:9][C:8]2[N:14]([S:15]([C:18]3[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=3)(=[O:17])=[O:16])[S:1](=[O:3])(=[O:2])[O:6][C:7]=2[CH:12]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24648Sulfuryl chlorideHCID 15183276HCID 15183276, compound

Product 1

HCID 18533223HCID 18533223, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-78 °C

Procedure

At −78° C., a solution of sulfuryl chloride (450 μl, 5.41 mmol) in CH2Cl2 (10 ml) is slowly added dropwise to a solution of N-(2-hydroxy-4-methylphenyl)-4-methylbenzenesulfonamide (1.5 g, 5.41 mmol) and triethylamine (1.5 ml), and the mixture is stirred at −78° C. for one hour. After thawing to RT, the solvent is distilled off under reduced pressure and the residue is purified by RP chromatography.

Workup

  1. customAfter thawing to RT
  2. distillationthe solvent is distilled off under reduced pressure
  3. customthe residue is purified by RP chromatography

Sources & evidence

ORD record
ord-001a9ccd5a40476aac8f451d7f7ce5d0
Source dataset
uspto-grants-2007_05
Patent number
US07211592B2

Reaction notes

Loading…