Dimethylamine → 4-dimethylaminomethyl-6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 1348711Notes

Reaction equation

HRID 1348711 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([CH2:21]OS(C)(=O)=O)[C:13](=[O:20])[N:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:27][NH:28][CH3:29]>>[CH3:27][N:28]([CH2:21][C:12]1[C:13](=[O:20])[N:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[N:15]=[C:10]([C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=2)[CH:11]=1)[CH3:29]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 866059726-(3-fluoro-4-methoxyphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 219914794-dimethylaminomethyl-6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-2H-pyridazin-3-oneYield 88.6%

Procedure

Following the procedure of Example 7, 6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 88.6%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-16d86800bf524c11af02d9c6acedba3a
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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