1-Methylpiperazine → 6-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 1348723Notes

Reaction equation

HRID 1348723 reaction equation
[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH2:18]OS(C)(=O)=O)[C:10](=[O:17])[N:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:12]=2)=[CH:3][CH:2]=1.[CH3:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH2:18][N:34]3[CH2:35][CH2:36][N:31]([CH3:30])[CH2:32][CH2:33]3)[C:10](=[O:17])[N:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:12]=2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 219915756-(4-biphenylyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 219916926-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 68.2%

Procedure

Following the procedure of Example 1(10), 6-(4-biphenylyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 68.2%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9e0f0e25bf7648ffb0c395d8f8783788
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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