Bromide ion → 5-(Hydroxymethyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Reaction equation
[Br-:29].[Br:1][c:2]1[c:3]([CH2:18][c:19]2[c:20]([C:25]([F:26])([F:27])[F:28])[cH:21][cH:22][cH:23][cH:24]2)[s:4][c:5]2[n:6]([CH2:14][CH:15]([CH3:16])[CH3:17])[c:7](=[O:13])[n:8]([CH3:12])[c:9](=[O:11])[c:10]12.[CH2:30]([Mg+:31])[CH:32]([CH3:33])[CH3:34].[O:35]=[C:36]=[O:37].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1>>[c:2]1([CH2:36][OH:35])[c:3]([CH2:18][c:19]2[c:20]([C:25]([F:26])([F:27])[F:28])[cH:21][cH:22][cH:23][cH:24]2)[s:4][c:5]2[n:6]([CH2:14][CH:15]([CH3:16])[CH3:17])[c:7](=[O:13])[n:8]([CH3:12])[c:9](=[O:11])[c:10]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-ae2ffb3fadc94131ad4dbed6b907347e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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