Pyrrolidine → HCID 21991683, compound

HRID 1348756Notes

Reaction equation

HRID 1348756 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([F:26])[CH:19]=3)=[N:6]2)[CH2:3][CH2:2]1.[NH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12][N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[CH:8][C:7]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([F:26])[CH:19]=3)=[N:6]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 219916182-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-meth anesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 21991683HCID 21991683, compoundYield 75.9%

Procedure

Following the procedure of Example 1(10), 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and pyrrolidine were reacted to yield the title compound as a yellow oil (yield: 75.9%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f4245b4c37dc48219574404792ee4b36
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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