反应详情

2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline (30 mg) was dissolved in chloroform (3 ml) to prepare a solution. Triethylamine (0.3 ml) and a solution of triphosgene (27 mg) in chloroform (0.2 ml) were then added thereto, and the mixture was stirred at room temperature for 30 min. Next, a solution of 2-amino-4-t-butylthiazole (64 mg) in chloroform (0.6 ml) was added thereto, and the mixture was further stirred at room temperature overnight. Water was added to the reaction solution, and the mixture was subjected to separatory extraction with chloroform. The extract was washed with saturated brine and was dried over anhydrous sodium sulfate. The organic layer was concentrated under the reduced pressure, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give 14 mg of the title compound.

1. customto prepare a solution
2. stirringthe mixture was further stirred at room temperature overnight
3. extractionthe mixture was subjected to separatory extraction with chloroform
4. washThe extract was washed with saturated brine
5. dry with materialwas dried over anhydrous sodium sulfate
6. concentrationThe organic layer was concentrated under the reduced pressure
7. customthe residue was purified by chromatography on silica gel