HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348921Generated: October 29, 2026
(2H-1,3-Benzodioxol-5-yl)hydrazine--hydrogen chloride (1/1) → ethyl 5-acetyl-1-(1,3-benzodioxol-5-yl)-8-nitro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate
https://huagongshe.com/reaction/1348921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (2H-1,3-Benzodioxol-5-yl)hydrazine--hydrogen chloride (1/1) | HCID 22291622 | — |
| Reactant | Ethyl (1-acetyl-6-nitro-4-oxo-1,2,3,4-tetrahydroquinolin-3-yl)(oxo)acetate | HCID 58859529 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | ethyl 5-acetyl-1-(1,3-benzodioxol-5-yl)-8-nitro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate | HCID 21092643 | 78% |
Reaction Steps
The material of Step 3 (1.1 g, 0.00331 mol) and 1-(1,3-benzodioxol-5-yl)hydrazine hydrochloride (500 mg, 0.00265 mol) were combined in acetic acid (10 mL) and heated to 60° C. for 5 hours. The suspension was then cooled and filtered to give the product as a brown solid. 930 mg (MW=450.4 g/mol, 78% yield). LC/MS m/z=451.5 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07211597B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-a920323d7410465a9b5479cc98aec03f |
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| Source note | uspto-grants-2007_05 |
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