HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348923Generated: October 30, 2026
Ammonia → 5-Acetyl-8-amino-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1h-pyrazolo[4,3-c]quinoline-3-carboxamide acetate
https://huagongshe.com/reaction/1348923
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | ethyl 5-acetyl-8-amino-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate | HCID 21092645 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Acetyl-8-amino-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1h-pyrazolo[4,3-c]quinoline-3-carboxamide acetate | HCID 10138855 | 93% |
Reaction Steps
The material of Step 5 (450 mg, 0.00094 mol) was dissolved in ethanol (10 mL) and NH3 (10 mL), and the resulting reaction mixture was heated to 120° C. and shaken for 20 hours at 600 psi. The reaction was then cooled and vented for 2 hours. The resulting solution was concentrated in vacuo to give the product as a brown glass. 340 mg (MW=391.38, 93% yield). LC/MS m/z=392.05 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07211597B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-7aef8dee30e047c495af187b3b0aa7d9 |
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| Source note | uspto-grants-2007_05 |
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