ethyl 5-acetyl-1-(4-fluorophenyl)-8-nitro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate → ethyl 5-acetyl-8-amino-1-(4-fluorophenyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate

HRID 1348928Notes

Reaction equation

HRID 1348928 reaction equation
[C:1]([N:4]1[C:13]2[CH:12]=[CH:11][C:10]([N+:14]([O-])=O)=[CH:9][C:8]=2[C:7]2[N:17]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[N:18]=[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:6]=2[CH2:5]1)(=[O:3])[CH3:2]>C(O)(=O)C>[C:1]([N:4]1[C:13]2[CH:12]=[CH:11][C:10]([NH2:14])=[CH:9][C:8]=2[C:7]2[N:17]([C:25]3[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=3)[N:18]=[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 21092644ethyl 5-acetyl-1-(4-fluorophenyl)-8-nitro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylate

Product 1

HCID 21092646ethyl 5-acetyl-8-amino-1-(4-fluorophenyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline-3-carboxylateYield 91%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The product was obtained as the acetic acid salt from the material from step 1 (10 g, 0.0236 mol) and by the method of Example 17. 9.8 g. (FW=454.45, 91% yield). LC/MS m/z=395 (m+1).

Sources & evidence

ORD record
ord-c47904afd3ea4bbc90762751b04b2993
Source dataset
uspto-grants-2007_05
Patent number
US07211597B2

Reaction notes

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