HRID1349030

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID60993

2-Aminoethyldiethylamine

C6H16N2

HCID84151

[1,1'-Biphenyl]-4-carbonyl chloride

C13H9ClO

结构：CC(C)(C)OC(=O)N1CC(=Cc2ccccc2)C[C@H]1C(=O)O

HCID69250545

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCNC(=O)[C@@H]1CC(=Cc2ccccc2)CN1C(=O)c1ccc(-c2ccccc2)cc1

HCID69249160

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained in 90% purity by LC/MS. MS(ESI+): m/z=482.4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-098589bb298448219eb6516591d07376
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH:1](=[C:8]1[CH2:12][N:11]([C:13]([O:15]C(C)(C)C)=O)[C@H:10]([C:20]([OH:22])=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:23]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:28]=[CH:27][C:26](C(Cl)=O)=[CH:25][CH:24]=1.[CH2:38]([N:40]([CH2:44][CH3:45])[CH2:41][CH2:42][NH2:43])[CH3:39]>>[CH:1](=[C:8]1[CH2:12][N:11]([C:13]([C:35]2[CH:34]=[CH:33][C:32]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:37][CH:36]=2)=[O:15])[C@H:10]([C:20]([NH:43][CH2:42][CH2:41][N:40]([CH2:44][CH3:45])[CH2:38][CH3:39])=[O:22])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1