HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethylethylenediamine → (2S,4EZ)-4-benzylidene-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[2-(diethylamino)-ethyl]-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethylethylenediamine | HCID 60993 | — |
| Reactant | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| Reactant | (2S,4EZ)-4benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 69250545 | — |
| Product | (2S,4EZ)-4-benzylidene-1-([1,1'-biphenyl]-4-ylcarbonyl)-N-[2-(diethylamino)-ethyl]-2-pyrrolidinecarboxamide | HCID 69249160 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained in 90% purity by LC/MS. MS(ESI+): m/z=482.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-098589bb298448219eb6516591d07376 |
| Source note | uspto-grants-2007_05 |