N-Methylbenzylamine → HCID 69251313, compound

HRID 1349054Notes

Reaction equation

HRID 1349054 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[O:18]([C:25]1[CH:33]=[CH:32][C:28](C(Cl)=O)=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[CH2:34]([NH:41][CH3:42])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH2:34]([N:41]([CH3:42])[C:15]([C@@H:9]1[CH2:10][C:11](=[CH:13][Cl:14])[CH2:12][N:8]1[C:6](=[O:7])[C:28]1[CH:27]=[CH:26][C:25]([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:33][CH:32]=1)=[O:17])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

4

Reactant 3

HCID 7669N-MethylbenzylamineHCID 741934-Phenoxybenzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69251313HCID 69251313, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and N-benzyl-N-methylamine the title compound was obtained in 61% purity by LC/MS. MS(ESI+): m/z=461.4.

Sources & evidence

ORD record
ord-33e349135d8941738b0195636e8e07bc
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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