HRID1349062

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77771

p-Chlorophenoxyacetyl chloride

C8H6Cl2O2

HCID79832

3,4-Dimethoxybenzylamine

C9H13NO2

结构：CC(C)(C)OC(=O)N1CC(=Cc2ccccc2)C[C@H]1C(=O)O

HCID69250545

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CNC(=O)[C@@H]2CC(=Cc3ccccc3)CN2C(=O)COc2ccc(Cl)cc2)cc1OC

HCID69455967

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 49% purity by LC/MS. MS(ESI+): m/z=521.6.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-953a80198d0a4f21ad037e523a15e658
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH:1](=[C:8]1[CH2:12][N:11]([C:13]([O:15]C(C)(C)C)=O)[C@H:10]([C:20]([OH:22])=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:23][C:24]1[CH:34]=[CH:33][C:27]([O:28][CH2:29]C(Cl)=O)=[CH:26][CH:25]=1.[CH3:35][O:36][C:37]1[CH:38]=[C:39]([CH:42]=[CH:43][C:44]=1[O:45][CH3:46])[CH2:40][NH2:41]>>[CH:1](=[C:8]1[CH2:12][N:11]([C:13](=[O:15])[CH2:29][O:28][C:27]2[CH:26]=[CH:25][C:24]([Cl:23])=[CH:34][CH:33]=2)[C@H:10]([C:20]([NH:41][CH2:40][C:39]2[CH:42]=[CH:43][C:44]([O:45][CH3:46])=[C:37]([O:36][CH3:35])[CH:38]=2)=[O:22])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1