HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Chlorophenoxyacetyl chloride → (2S,4EZ)-4-benzylidene-1-[(4-chlorophenoxy)acetyl]-N-(3,4-dimethoxy-benzyl)-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Chlorophenoxyacetyl chloride | HCID 77771 | — |
| Reactant | Veratrylamine | HCID 79832 | — |
| Reactant | (2S,4EZ)-4benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 69250545 | — |
| Product | (2S,4EZ)-4-benzylidene-1-[(4-chlorophenoxy)acetyl]-N-(3,4-dimethoxy-benzyl)-2-pyrrolidinecarboxamide | HCID 69455967 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 49% purity by LC/MS. MS(ESI+): m/z=521.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-953a80198d0a4f21ad037e523a15e658 |
| Source note | uspto-grants-2007_05 |