O-Phenylenediamine → HCID 131726372, compound

HRID 1349071Notes

Reaction equation

HRID 1349071 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16](O)=O)=[O:7])(C)(C)C.[C:19]1([CH:25]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)C(Cl)=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[C:35]1([NH2:42])[C:36]([NH2:41])=[CH:37][CH:38]=[CH:39][CH:40]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[NH:42][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[N:41]=2)[N:8]([C:6](=[O:7])[CH:25]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:12]1

Participants

4

Reactant 3

HCID 7243O-PhenylenediamineHCID 746372,2-Diphenylacetyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726372HCID 131726372, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 1,2-benzenediamine the title compound was obtained in 72% purity by LC/MS. MS(ESI+): m/z=425.4.

Sources & evidence

ORD record
ord-371af834f6bf4bb8960a224bf63132f8
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…