O-Phenylenediamine → HCID 69250511, compound

HRID 1349072Notes

Reaction equation

HRID 1349072 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10](O)=O)=[O:7])(C)(C)C.[C:17]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:22]=[CH:21][C:20](C(Cl)=O)=[CH:19][CH:18]=1.[C:32]1([NH2:39])[C:33]([NH2:38])=[CH:34][CH:35]=[CH:36][CH:37]=1>>[C:26]1([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:27]=[CH:28][C:29]([C:6]([N:8]2[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]2[C:10]2[NH:39][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[N:38]=2)=[O:7])=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 7243O-PhenylenediamineHCID 841514-Phenylbenzoyl chlorideHCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 69250511HCID 69250511, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, [1,1′-biphenyl]-4-carbonyl chloride, and 1,2-benzenedi-amine the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m/z=380.4.

Sources & evidence

ORD record
ord-9bb5911dfdd7422cb01b5b60411ff09b
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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