2-Methoxyethylamine → HCID 69551469, compound

HRID 1349073Notes

Reaction equation

HRID 1349073 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[C:18]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]=[CH:22][C:21](C(Cl)=O)=[CH:20][CH:19]=1.[CH3:33][O:34][CH2:35][CH2:36][NH2:37]>>[C:27]1([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:28]=[CH:29][C:30]([C:6]([N:8]2[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][CH:9]2[C:15]([NH:37][CH2:36][CH2:35][O:34][CH3:33])=[O:17])=[O:7])=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 841514-Phenylbenzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69551469HCID 69551469, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tertbutoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 2-methoxyethylamine the title compound was obtained in 55% purity by LC/MS. MS(ESI+): m/z=399.6.

Sources & evidence

ORD record
ord-76458dbe5cdd4d5f81f0edd3d82152f5
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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