N,N-Diethylethylenediamine → HCID 131725476, compound

HRID 1349102Notes

Reaction equation

HRID 1349102 reaction equation
[CH2:1]([O:3][N:4]=[C:5]1[CH2:9][NH:8][CH:7]([C:10]([OH:12])=O)[CH2:6]1)[CH3:2].[C:13]1([CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20](Cl)=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH2:29]([N:31]([CH2:35][CH3:36])[CH2:32][CH2:33][NH2:34])[CH3:30]>>[CH2:29]([N:31]([CH2:35][CH3:36])[CH2:32][CH2:33][NH:34][C:10]([C@@H:7]1[CH2:6][C:5](=[N:4][O:3][CH2:1][CH3:2])[CH2:9][N:8]1[C:20](=[O:21])[CH:19]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])[CH3:30]

Participants

4

Reactant 3

HCID 60993N,N-DiethylethylenediamineHCID 746372,2-Diphenylacetyl chlorideHCID 131726373HCID 131726373, compound

Product 1

HCID 131725476HCID 131725476, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained in 50% purity by LC/MS. MS(ESI+): m/z=465.4.

Sources & evidence

ORD record
ord-f32947e7b4bc471e9202a6d780594b29
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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