Piperidine → HCID 131725534, compound

HRID 1349182Notes

Reaction equation

HRID 1349182 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][N:20]([CH3:27])[CH2:21][CH2:22][CH2:23]C(Cl)=O.[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:18])[N:8]([C:6](=[O:7])[CH2:23][CH2:22][CH2:21][N:20]([CH3:27])[CH3:19])[CH2:12]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 150876904-(Dimethylamino)butanoyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725534HCID 131725534, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4(dimethylamino)butanoyl chloride, and piperidine the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z=339.2.

Sources & evidence

ORD record
ord-de9c97ad0d8f4a29aa9a677521726831
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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