2-Methoxyethylamine → HCID 131725555, compound

HRID 1349207Notes

Reaction equation

HRID 1349207 reaction equation
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[C:21]([C:23]1[CH:31]=[CH:30][C:26](C(Cl)=O)=[CH:25][CH:24]=1)#[N:22].[CH3:32][O:33][CH2:34][CH2:35][NH2:36]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11](=[O:13])[C:26]2[CH:25]=[CH:24][C:23]([C:21]#[N:22])=[CH:31][CH:30]=2)[C@H:8]([C:18]([NH:36][CH2:35][CH2:34][O:33][CH3:32])=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 801724-Cyanobenzoyl chlorideHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725555HCID 131725555, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2-methoxyethylamine the title compound was obtained in 44% purity by LC/MS. MS(ESI+): m/z=371.0.

Sources & evidence

ORD record
ord-2228d9e15ed14814851f0850c564f12f
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…