1-(Aminomethyl)cyclohexan-1-ol → HCID 131726383, compound

HRID 1349241Notes

Reaction equation

HRID 1349241 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:33]=[CH:32][C:28](C(O)=O)=[CH:27][CH:26]=2)[CH:20]=1.[NH2:34][CH2:35][C:36]1([OH:42])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[OH:42][C:36]1([CH2:35][NH:34][C:16]([C@@H:9]2[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]2[C:6](=[O:7])[C:28]2[CH:27]=[CH:26][C:25]([C:21]3[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=3)=[CH:33][CH:32]=2)=[O:18])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

Participants

4

Reactant 3

HCID 776141-(Aminomethyl)cyclohexan-1-olHCID 15152444-Pyridin-3-yl-benzoic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726383HCID 131726383, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and 1-(aminomethyl)cyclohexanol, the title compound was obtained in 69% purity by HPLC. MS(ESI+): m/z=451.

Sources & evidence

ORD record
ord-b390fbf2397f4c2483342f7fbe29726c
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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