3-Hydroxypiperidine → HCID 131726394, compound

HRID 1349267Notes

Reaction equation

HRID 1349267 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:33]=[CH:32][C:28](C(O)=O)=[CH:27][CH:26]=2)[CH:20]=1.[NH:34]1[CH2:39][CH2:38][CH2:37][CH:36]([OH:40])[CH2:35]1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]([N:34]2[CH2:39][CH2:38][CH2:37][CH:36]([OH:40])[CH2:35]2)=[O:18])[N:8]([C:6](=[O:7])[C:28]2[CH:27]=[CH:26][C:25]([C:21]3[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=3)=[CH:33][CH:32]=2)[CH2:12]1

Participants

4

Reactant 3

HCID 232933-HydroxypiperidineHCID 15152444-Pyridin-3-yl-benzoic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726394HCID 131726394, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (3RS)-3-piperidinol, the title compound was obtained in 84% purity by HPLC. MS(ESI+): m/z=423.

Sources & evidence

ORD record
ord-d2decafe29b84c43b0d31e52378235b5
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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