1-(4-(Trifluoromethyl)phenyl)piperazine → HCID 131725664, compound

HRID 1349334Notes

Reaction equation

HRID 1349334 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29](C(O)=O)=[CH:28][CH:27]=1.[F:35][C:36]([F:50])([F:49])[C:37]1[CH:42]=[CH:41][C:40]([N:43]2[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]2)=[CH:39][CH:38]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]([N:46]2[CH2:45][CH2:44][N:43]([C:40]3[CH:39]=[CH:38][C:37]([C:36]([F:49])([F:50])[F:35])=[CH:42][CH:41]=3)[CH2:48][CH2:47]2)=[O:18])[N:8]([C:6]([C:29]2[CH:28]=[CH:27][C:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH3:19])=[CH:31][CH:30]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 1217181-(4-(Trifluoromethyl)phenyl)piperazineHCID 27598152'-Methyl-biphenyl-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725664HCID 131725664, compound

Procedure

Following the general method as outlined in Example 22, staring from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and 1-[4-(trifluoromethyl)phenyl]piperazine, the title compound was obtained in 89% purity by HPLC. MS(ESI+): m/z=565.

Sources & evidence

ORD record
ord-3c2b18bb8bd04566b995068d1cda3fc4
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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