HCID 10272812, compound → HCID 69113779, compound

HRID 1349445Notes

Reaction equation

HRID 1349445 reaction equation
[CH3:1][C:2]([NH:15][CH2:16][C@@H:17]([OH:30])[CH2:18][O:19][CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[CH3:21])([CH3:14])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1.C(OCC)(=O)C.[ClH:37]>C(OCC)C>[ClH:37].[CH3:1][C:2]([NH:15][CH2:16][C@@H:17]([OH:30])[CH2:18][O:19][CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[CH3:21])([CH3:14])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 10272812HCID 10272812, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69113779HCID 69113779, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

(2R)-1-[1,1-Dimethyl-2-(naphthalen-2-yl)ethylamino]-3-[1-(2-methoxyphenyl)ethoxy]propan-2-ol (141 mg) obtained in Example 4 was dissolved in diethyl ether (5 ml), and 4N hydrogen chloride-ethyl acetate solution was added. The reaction mixture was concentrated under reduced pressure and diethyl ether (5 ml) was added. The mixture was concentrated under reduced pressure to give the title compound (154 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure and diethyl ether (5 ml)
  2. additionwas added
  3. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-78c4df7c1de14d2c991649e8a6b72a5a
Source dataset
uspto-grants-2007_05
Patent number
US07211685B2

Reaction notes

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