Trifluoroacetic acid → HCID 54705417, compound

HRID 1349465Notes

Reaction equation

HRID 1349465 reaction equation
FC(F)(F)C(O)=O.C([O:15][C:16]1[C:17](=[O:38])[CH:18]=[CH:19][N:20]2[CH:25]=[CH:24][N:23]([CH2:26][CH2:27][CH2:28][C:29]3[C:34]([Cl:35])=[CH:33][CH:32]=[CH:31][C:30]=3[Cl:36])[C:22](=[O:37])[C:21]=12)C1C=CC=CC=1>>[Cl:35][C:34]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:36])[C:29]=1[CH2:28][CH2:27][CH2:26][N:23]1[CH:24]=[CH:25][N:20]2[CH:19]=[CH:18][C:17](=[O:38])[C:16]([OH:15])=[C:21]2[C:22]1=[O:37]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23077613HCID 23077613, compound

Product 1

HCID 54705417HCID 54705417, compoundYield 95.6%

Procedure

Trifluoroacetic acid (1 ml) was added to 9-benzyloxy-2-[3-(2,6-dichlorophenyl)propyl]-2H-pyrido[1,2-a]pyrazine-1,8-dione (120 mg) obtained in the previous step and the mixture was left standing at room temperature for 1 hr. The solvent was evaporated, toluene was added, and the mixture was concentrated, which operations were performed twice. The obtained crystals were washed with diisopropyl ether to give 2-[3-(2,6-dichlorophenyl)propyl]-9-hydroxy-2H-pyrido[1,2-a]pyrazine-1,8-dione (92 mg).

Workup

  1. customobtained in the previous step
  2. waitthe mixture was left
  3. customThe solvent was evaporated
  4. additiontoluene was added
  5. concentrationthe mixture was concentrated
  6. washThe obtained crystals were washed with diisopropyl ether

Sources & evidence

ORD record
ord-b50f47d7bb6141fa928cb89e941a9b43
Source dataset
uspto-grants-2007_05
Patent number
US07211572B2

Reaction notes

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