Hydrochloric Acid → HCID 178524905, compound

HRID 1349467Notes

Reaction equation

HRID 1349467 reaction equation
[OH-].[Na+].[CH2:3]([O:10][C:11]1[C:12]([C:18]([O:20]C)=[O:19])=[N:13][CH:14]=[N:15][C:16]=1[OH:17])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[CH2:3]([O:10][C:11]1[C:12]([C:18]([OH:20])=[O:19])=[N:13][CH:14]=[N:15][C:16]=1[OH:17])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178499120HCID 178499120, compound

Product 1

HCID 178524905HCID 178524905, compoundYield 50.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methanol (6 ml) and 1N aqueous sodium hydroxide solution (2.5 ml) were added to methyl 5-benzyloxy-6-hydroxypyrimidine-4-carboxylate (530 mg) obtained in the previous step, and the mixture was stirred at room temperature for 1 hr. 2N Hydrochloric acid (2.5 ml) was added to the reaction mixture, and methanol was evaporated under reduced pressure. The precipitate was collected by filtration, washed with water and dried to give 5-benzyloxy-6-hydroxypyrimidine-4-carboxylic acid (253 mg).

Workup

  1. customobtained in the previous step
  2. customwas evaporated under reduced pressure
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-669918212c7b436d8a742c97786c0910
Source dataset
uspto-grants-2007_05
Patent number
US07211572B2

Reaction notes

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