反应详情

温度

50 °C

To a solution of 3-benzyloxy-5-bromo-4-oxo-4H-pyran-2-carboxylic acid 3-chlorobenzylamide (2.0 g) obtained in Example 161, Step 1 in tetrahydrofuran (10 ml)-ethanol (10 ml) was added 2-aminoethanol (0.33 ml) and the mixture was stirred at room temperature and at 50° C. respectively for 30 min. The solvent was evaporated and the residue was crystallized from ethyl acetate-diisopropyl ether to give 3-benzyloxy-5-bromo-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide (1.95 g).

1. customThe solvent was evaporated
2. customthe residue was crystallized from ethyl acetate-diisopropyl ether