Hydrochloric Acid → HCID 54683368, compound

HRID 1349513Notes

Reaction equation

HRID 1349513 reaction equation
C([O:8][C:9]1[C:10](=[O:34])[C:11]([C:29]2[S:30][CH:31]=[CH:32][N:33]=2)=[CH:12][N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15](=[O:28])[C:14]=12)C1C=CC=CC=1.[ClH:35]>C(O)(=O)C>[ClH:35].[OH:8][C:9]1[C:10](=[O:34])[C:11]([C:29]2[S:30][CH:31]=[CH:32][N:33]=2)=[CH:12][N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15](=[O:28])[C:14]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23077654HCID 23077654, compound

Product 1

HCID 54683368HCID 54683368, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 9-benzyloxy-2-(3-phenylpropyl)-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (27 mg) in acetic acid (1 ml) was added conc. aqueous hydrochloric acid (0.5 ml) and the mixture was stirred at 90° C. for 2 hr. The solvent was evaporated and ethyl acetate was added to the residue. The obtained solid was collected by filtration to give 9-hydroxy-2-(3-phenylpropyl)-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione hydrochloride (25 mg).

Workup

  1. customThe solvent was evaporated
  2. additionethyl acetate was added to the residue
  3. filtrationThe obtained solid was collected by filtration

Sources & evidence

ORD record
ord-7081f892ae0e45f799412a832183cb73
Source dataset
uspto-grants-2007_05
Patent number
US07211572B2

Reaction notes

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