Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile
Reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][C:3]=1[CH:10]=O.O.[NH2:13][NH2:14]>>[NH:13]1[C:2]2[C:3](=[CH:4][C:5]([C:8]#[N:9])=[CH:6][CH:7]=2)[CH:10]=[N:14]1Participants
3
Procedure
4-Fluoro-3-formylbenzenecarbonitrile (4.6 g, 30.85 mmol) was suspended in 20 mL of hydrazine mono-hydrate and the reaction mixture was stirred at room temperature for 48 hours. The title compound was isolated by filtration as a white solid, was washed with small portions of distilled water, and was dried in a vacuum (3.6 g, 81% yield).
Sources & evidence
- ORD record
- ord-f3ef2f4bcb7d42458e5f86393f574d82
- Source dataset
- uspto-grants-2007_05
- Patent number
- US07211594B2
Reaction notes
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