Hydrochloric Acid → HCID 178509531, compound

HRID 1349657Notes

Reaction equation

HRID 1349657 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]#[N:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[Br:12]Br.Cl>CO.[OH-].[Na+]>[Br:12][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[C:6]([C:10]#[N:11])[CH:5]=2)[NH:1][N:2]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 24408BromineHCID 111263841H-Indazole-5-carbonitrile

Product 1

HCID 178509531HCID 178509531, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent2×

Conditions

Temperature
40 °C

Procedure

1H-Indazole-5-carbonitrile (5.3 g, 36.8 mmol) was dissolved in methanol (60 mL) and aqueous sodium hydroxide (30 mL). Bromine (7.07 g, 44.4 mmol) in solution in 2.0 N aqueous sodium hydroxide (30 mL) was added with a disposable pipet. The reaction mixture was then heated to 40° C. for 1.5 hours. The reaction was cooled to room temperature and acidified with 6.0 N aqueous hydrochloric acid. The resulting solid was collected by filtration and washed 3 times with 20-mL portions of water. The solid was dried under vacuum for 1 day. The solid was used without further purification. (7.54 g, 92% yield): 1H NMR (CDCl3) δ 13.3 (br s, 1H), 8.0 (s, 1H), 7.5 (s, 2H); ES-MS (m/z) 224 [M+1]+.

Workup

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed 3 times with 20-mL portions of water
  4. customThe solid was dried under vacuum for 1 day
  5. customThe solid was used without further purification

Sources & evidence

ORD record
ord-0ca97937423f41449ce131a1f0446ad7
Source dataset
uspto-grants-2007_05
Patent number
US07211594B2

Reaction notes

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