Dichloromethane → 7-(1,4'-bipiperidin-1'-yl)-5-chloro-1-(2,6-difluorophenyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Reaction equation
[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[N:11]([c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[C:12](=[O:15])[NH:13][CH2:14]2.[Cl:45][CH2:46][Cl:47].[N:24]1([CH:30]2[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([N:33]3[CH2:32][CH2:31][CH:30]([N:24]4[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]4)[CH2:35][CH2:34]3)[n:7]1)[N:11]([c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[C:12](=[O:15])[NH:13][CH2:14]2Participants
5
Sources & evidence
- ORD record
- ord-3bb09d99995b466bba93104e6e2de956
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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