5-(2-Bromoethoxy)-7-fluoro-2-methylquinoline → 8-{1-[2-(7-Fluoro-2-methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4-methyl-4H-benzo[1,4]oxazin-3-one

HRID 1349965Notes

Reaction equation

HRID 1349965 reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH2:12][CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:6]=2[O:5][CH2:4][C:3]1=[O:19].Br[CH2:21][CH2:22][O:23][C:24]1[CH:33]=[C:32]([F:34])[CH:31]=[C:30]2[C:25]=1[CH:26]=[CH:27][C:28]([CH3:35])=[N:29]2>>[F:34][C:32]1[CH:31]=[C:30]2[C:25]([CH:26]=[CH:27][C:28]([CH3:35])=[N:29]2)=[C:24]([O:23][CH2:22][CH2:21][N:16]2[CH2:17][CH2:18][CH:13]([CH2:12][C:11]3[C:6]4[O:5][CH2:4][C:3](=[O:19])[N:2]([CH3:1])[C:7]=4[CH:8]=[CH:9][CH:10]=3)[CH2:14][CH2:15]2)[CH:33]=1

Participants

3

Reactant 2

HCID 179651425-(2-Bromoethoxy)-7-fluoro-2-methylquinolineHCID 210937454-methyl-8-(piperidin-4-ylmethyl)4H-benzo[1,4]oxazin-3-one

Product 1

HCID 102172008-{1-[2-(7-Fluoro-2-methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4-methyl-4H-benzo[1,4]oxazin-3-one

Procedure

The title compound was prepared from 4-methyl-8-(piperidin-4-ylmethyl)-4H-benzo[1,4]oxazin-3-one and 5-(2-bromoethoxy)-7-fluoro-2-methylquinoline in a similar manner to Example 1.

Sources & evidence

ORD record
ord-41357284c1584299bcda5ab6dbdaee04
Source dataset
uspto-grants-2007_05
Patent number
US07214674B2

Reaction notes

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