反应详情

温度

50 °C

To a solution of the ester of Example 6 in THF (0.8 mL) was added a solution of KOH (14 mg, 0.255 mmol) in H2O (0.2 mL). The mixture was stirred at 50° C., then concentrated to remove THF. The aqueous phase was washed with ethyl ether, then the aqueous phase was acidified until pH 3–4 was reached. The acidified solution was extracted with Et2O or EtOAc (3×), dried over MgSO4, filtered and concentrated in vacuo to give a white solid.

1. concentrationconcentrated
2. customto remove THF
3. washThe aqueous phase was washed with ethyl ether
4. extractionThe acidified solution was extracted with Et2O or EtOAc (3×)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto give a white solid