反应详情

To a solution of 4-bromo-3-methylbenzoyl chloride (0.5 g, 2 mmol) in toluene (6 mL) was added N-methylpiperazine (0.5 mL, 4 mmol, 2 equiv.). The resulting mixture was stirred overnight, The precipitate was filtered and the filtrate was concentrated under reduced pressure. The residue was taken into ethyl acetate and washed with water. The organic layer was dried over sodium sulfate, concentrated under reduced pressure to give 0.2 g (34% yield) of intermediate 11.

1. filtrationThe precipitate was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. washwashed with water
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated under reduced pressure