Potassium Fluoride → HCID 10156609, compound

HRID 1350059Notes

Reaction equation

HRID 1350059 reaction equation
[OH:1][CH:2]1[CH2:18][N:6]2[C:7](=[O:17])[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)[N:10]=[C:5]2[NH:4][CH2:3]1.CS(O[CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[F:33])(=O)=O.[F-].[K+]>C(#N)C>[F:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[CH2:26][CH2:25][CH2:24][N:4]1[C:5]2=[N:10][C:9]([C:11]3[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=3)=[CH:8][C:7](=[O:17])[N:6]2[CH2:18][CH:2]([OH:1])[CH2:3]1

Participants

5

Reactant 3

HCID 522689Potassium FluorideHCID 120714612-Fluorophenylpropyl mesylateHCID 135797776HCID 135797776, compound

Product 1

HCID 10156609HCID 10156609, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of 1.0 g (4.09 mmol) of 7-hydroxy-2-(pyridin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one and 0.95 g (4.09 mmol) of 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene in 100 ml of anhydrous acetonitrile was treated with 4.1 g (1.42 mmol) of potassium fluoride suspended on alumina (Fluka) and the resulting mixture was heated at 80° C. for 24 h.

Sources & evidence

ORD record
ord-14a87bc75a2940c7a706a08d083ecd49
Source dataset
uspto-grants-2007_05
Patent number
US07214682B2

Reaction notes

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