Potassium Carbonate → 2,2-Dimethyl-7-(pyridin-4-yl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

HRID 1350063Notes

Reaction equation

HRID 1350063 reaction equation
Br.[CH3:2][C:3]1([CH3:9])[NH:7][C:6]([NH2:8])=[N:5][CH2:4]1.[N:10]1[CH:15]=[CH:14][C:13]([C:16](=O)[CH2:17][C:18](OCC)=[O:19])=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:2][C:3]1([CH3:9])[CH2:4][N:5]2[C:18](=[O:19])[CH:17]=[C:16]([C:13]3[CH:14]=[CH:15][N:10]=[CH:11][CH:12]=3)[N:8]=[C:6]2[NH:7]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 178510605,5-dimethyl-4,5-dihydro-1H-imidazol-2-amine hydrobromide

Product 1

HCID 1358117002,2-Dimethyl-7-(pyridin-4-yl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 4.5 g (23.2 mmol) of 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide, 2.99 g (15.46 mmol) of ethyl 3-(pyridin-4-yl)-3-oxopropionate and 4.27 g (30.89 mmol) of potassium carbonate in 100 ml of ethanol was heated at reflux temperature for 18 h.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature for 18 h.

Sources & evidence

ORD record
ord-7395084fd4e549ec9cf0104355a1bfad
Source dataset
uspto-grants-2007_05
Patent number
US07214682B2

Reaction notes

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