HCID 21094315, compound → HCID 21094312, compound

HRID 1350080Notes

Reaction equation

HRID 1350080 reaction equation
[C:1]([CH2:3][CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][N:6]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:5]1)#[N:2]>CO.N.[Ni]>[NH2:2][CH2:1][CH2:3][CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][N:6]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:5]1

Participants

5

Reactant 1

HCID 21094315HCID 21094315, compound

Product 1

HCID 21094312HCID 21094312, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

The compound obtained in Step I (6.3 g; 21 mmol) is dissolved in 150 ml of methanol saturated with NH3(g). The solution is poured into an autoclave and Raney nickel (600 mg) is added. The reaction mixture is then stirred at 60° C. and under a hydrogen pressure of 50 bars for 6 hours. After removal of the catalyst by filtration, the solution is evaporated under reduced pressure and the title compound is obtained in the form of a colourless oil.

Workup

  1. additionis added
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe solution is evaporated under reduced pressure

Sources & evidence

ORD record
ord-2e5f1a7b05c74ff987b4120d4df6b497
Source dataset
uspto-grants-2007_05
Patent number
US07214689B2

Reaction notes

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