Hydrochloric Acid → HCID 23064387, compound

HRID 1350082Notes

Reaction equation

HRID 1350082 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[N:10][CH:9]=[C:8]2[CH2:15]O.S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl.C(OCC)C>[Cl:19][CH2:15][C:8]1[C:7]2[C:12](=[CH:13][CH:14]=[C:5]([O:4][CH3:3])[CH:6]=2)[CH:11]=[N:10][CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 21094271HCID 21094271, compound

Product 1

HCID 23064387HCID 23064387, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

The hydrochloride of the compound obtained in Step B (1.09 g; 0.005 mol) is suspended in 50 ml of chloroform. Thionyl chloride (2.80 ml; 0.04 mol) is added and then the reaction mixture is heated at reflux for 24 hours with stirring. After evaporation under reduced pressure, the residue obtained is taken up in ethyl ether. The precipitate formed is suction-filtered off and recrystallised from acetonitrile to yield the title compound in the form of a white solid.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux for 24 hours
  3. customAfter evaporation under reduced pressure
  4. customthe residue obtained
  5. customThe precipitate formed
  6. filtrationis suction-filtered off
  7. customrecrystallised from acetonitrile

Sources & evidence

ORD record
ord-48b73efd8ba64b7c93e7d25f6e4d1490
Source dataset
uspto-grants-2007_05
Patent number
US07214689B2

Reaction notes

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