HCID 12988737, compound → HCID 12988738, compound

HRID 1350085Notes

Reaction equation

HRID 1350085 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[N:8][CH2:7][CH:6]2[CH2:13][CH2:14][CH2:15][C:16]([NH:18][CH3:19])=[O:17]>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH:6]2[CH2:13][CH2:14][CH2:15][C:16]([NH:18][CH3:19])=[O:17]

Participants

4

Reactant 1

HCID 12988737HCID 12988737, compound

Product 1

HCID 12988738HCID 12988738, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound obtained in Example 1 (54 mmol), in the form of a base, is dissolved in 50 ml of methanol and then palladium-on-carbon (150 mg) is added to the solution. The reaction mixture is stirred at ambient temperature and under hydrogen for 4 hours. After removal of the palladium-on-carbon by filtration, the organic phase is evaporated under reduced pressure. The oil obtained is purified by chromatography on silica gel to yield the title product in the form of a yellow oil.

Workup

  1. customAfter removal of the palladium-on-carbon
  2. filtrationby filtration
  3. customthe organic phase is evaporated under reduced pressure
  4. customThe oil obtained
  5. customis purified by chromatography on silica gel

Sources & evidence

ORD record
ord-5f34d1d393ad45159a917166b266a65e
Source dataset
uspto-grants-2007_05
Patent number
US07214689B2

Reaction notes

Loading…