Hydrochloric Acid → HCID 60077638, compound

A solution of tert-butyl(3R)-6-cyclohexyl-3-[3-(hydrazinocarbonyl)-1,2,4-oxadiazol-5-yl]hexanoate (preparation 71) (1.06 g, 2.76 mmol) in glacial AcOH (10 ml) was treated with 2M HCl (10 ml) and stirred at room temperature for 30 minutes. The reaction mixture was cooled to 0° C. before being treated with a solution of NaNO2 (278 mg, in 5 ml H2O) making sure the temperature never rose above 5° C. The reaction mixture was stirred at 0° C. for 30 minutes and then allowed to warm to room temperature before being heated at 85° C. until the evolution of gas a finished. The reaction mixture was neutralised with sat. Na2CO3 solution and extracted with EtOAc. The organic extract was washed with brine and the solvent removed under reduced pressure. The residue was treated with TFA (4 ml) and stirred at room temperature for 1 hour. The solvent was removed under reduced pressure and the residue azeotroped from toluene (×3) and DCM (×3) to afford the title compound as a foam (390 mg, 50%).

1. temperatureThe reaction mixture was cooled to 0° C.
2. customthe temperature never rose above 5° C
3. stirringThe reaction mixture was stirred at 0° C. for 30 minutes
4. temperatureto warm to room temperature
5. temperaturebefore being heated at 85° C. until the evolution of gas
6. extractionextracted with EtOAc
7. extractionThe organic extract
8. washwas washed with brine
9. customthe solvent removed under reduced pressure
10. additionThe residue was treated with TFA (4 ml)
11. stirringstirred at room temperature for 1 hour
12. customThe solvent was removed under reduced pressure
13. customthe residue azeotroped from toluene (×3) and DCM (×3)

ORD record

ord-c53092160fdf4f1583df985a3594475f

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07214694B2