HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-2-Methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | (S)-2-methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene | HCID 135797743 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-2-Methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride | HCID 136360200 | — |
Reaction Steps
Dissolve (S)-2-methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene in ethyl acetate add hydrochloride acid until the title compound precipates as the dihydrochloride salt as a yellow solid: mp 225° C.; mass spectrum (ion spray): m/z=417 (M+1); Analysis for C25H30Cl2N4S(0.3 H2O): calcd: C, 60.67; H, 6.23; N. 11.32; found: C, 60.76; H, 6.17; N, 11.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214673B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-672a877ba2854f8b978f244bf4549c48 |
| Source note | uspto-grants-2007_05 |