Hydrochloric Acid → (S)-2-Methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

HRID 1350358Notes

Reaction equation

HRID 1350358 reaction equation
[CH3:1][C:2]1[S:11][C:10]2[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=[C:5]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[C@@H:18]([CH2:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:17]3)[C:4]=2[CH:3]=1.[ClH:31].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>C(OCC)(=O)C>[ClH:31].[ClH:31].[CH3:1][C:2]1[S:11][C:10]2[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=[C:5]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[C@@H:18]([CH2:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:17]3)[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 135797743(S)-2-methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene

Product 1

HCID 136360200(S)-2-Methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Dissolve (S)-2-methyl-10-(4-methyl-3-phenethyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene in ethyl acetate add hydrochloride acid until the title compound precipates as the dihydrochloride salt as a yellow solid: mp 225° C.; mass spectrum (ion spray): m/z=417 (M+1); Analysis for C25H30Cl2N4S(0.3 H2O): calcd: C, 60.67; H, 6.23; N. 11.32; found: C, 60.76; H, 6.17; N, 11.13.

Sources & evidence

ORD record
ord-672a877ba2854f8b978f244bf4549c48
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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