1-Methylpiperazine → 10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-tert-butyl-4-(4-methyl-1-piperazinyl)-
Reaction equation
Cl.[C:2]([C:6]1[S:15][C:14]2[NH:13][C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[N:10]=[C:9]([NH2:20])[C:8]=2[CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[CH3:21][N:22]1[CH2:27][CH2:26]N[CH2:24][CH2:23]1>>[C:2]([C:6]1[S:15][C:14]2[NH:13][C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[N:10]=[C:9]([N:20]3[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]3)[C:8]=2[CH:7]=1)([CH3:5])([CH3:3])[CH3:4]Participants
3
Procedure
By a method similar to Example 59, using 2-tert-butyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride (1.00 g, 3.26 mmol) and N-methyl-piperazine (1.9 g, 19 mmol) to obtain the title compound (904 mg, 78%) as a yellow powder: mp 125–130° C. (dec): 1H NMR (CDCl3) δ 1.29 (s, 9H), 2.35 (s, 3H), 2.50 (m, 4H), 3.53 (m, 4H), 4.96 (s, 1H), 6.33 (s, 1H), 6.60 (d, 1H), 6.87 (t, 1H), 6.96 (t, 1H), 7.02 (d, 1).
Sources & evidence
- ORD record
- ord-85ab7fc1b72b42e9a07aec71ee5602df
- Source dataset
- uspto-grants-2007_05
- Patent number
- US07214673B2
Reaction notes
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