(S)-2-(2-Methoxy-benzyl)-piperazine → (S)-10-[3-(2-Methoxy-benzyl)-piperazin-1-yl]-2-methyl-4H-3-thia-1,4,9-triaza-benzo[f]azulene

HRID 1350454Notes

Reaction equation

HRID 1350454 reaction equation
[CH3:1][C:2]1[S:11][C:10]2[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=[C:5]([NH2:16])[C:4]=2[N:3]=1.[CH3:17][O:18][C:19]1[CH:31]=[CH:30][CH:29]=[CH:28][C:20]=1[CH2:21][C@H:22]1[CH2:27]N[CH2:25][CH2:24][NH:23]1>>[CH3:17][O:18][C:19]1[CH:31]=[CH:30][CH:29]=[CH:28][C:20]=1[CH2:21][C@@H:22]1[NH:23][CH2:24][CH2:25][N:16]([C:5]2[C:4]3[N:3]=[C:2]([CH3:1])[S:11][C:10]=3[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 69486818(S)-2-(2-Methoxy-benzyl)-piperazineHCID 1357977442-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine

Product 1

HCID 136005571(S)-10-[3-(2-Methoxy-benzyl)-piperazin-1-yl]-2-methyl-4H-3-thia-1,4,9-triaza-benzo[f]azuleneYield 35%

Procedure

By a similar method to the method of Example 460, using 2-methyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine(0.687 g, 2.98 mmol) and (S)-2-(2-methoxy-benzyl)-piperazine (0.615 g, 2.98 mmol) gives 0.437 g of the title compound as a yellow solid: mass spectrum (ion spray): m/z=420 (M+1); Analysis for C23H25N5OS(0.5 H2O): calcd: C, 64.46; H, 6.12; N, 16.34; found: C, 64.20; H, 5.77; N, 16.14.

Sources & evidence

ORD record
ord-dcc9bec59046402b8e9674fefeeb8545
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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