(S)-2-Phenethylpiperazine → (S)-2-Isopropyl-10-(3-phenethyl-piperazin-1-yl)4H-3-thia-1,4,9-triaza-benzo[f]azulene

HRID 1350458Notes

Reaction equation

HRID 1350458 reaction equation
[CH:1]([C:4]1[S:13][C:12]2[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=[C:7]([NH2:18])[C:6]=2[N:5]=1)([CH3:3])[CH3:2].[CH2:19]([C@H:27]1[CH2:32]N[CH2:30][CH2:29][NH:28]1)[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH:1]([C:4]1[S:13][C:12]2[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=[C:7]([N:18]3[CH2:30][CH2:29][NH:28][C@@H:27]([CH2:19][CH2:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:32]3)[C:6]=2[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 44828673(S)-2-PhenethylpiperazineHCID 1357977402-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine

Product 1

HCID 135932188(S)-2-Isopropyl-10-(3-phenethyl-piperazin-1-yl)4H-3-thia-1,4,9-triaza-benzo[f]azuleneYield 42.3%

Procedure

By using a similar method of Example 460, using 2-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine(1.47 g, 5.69 mmol) and (S)-2-phenethyl-piperazine (1.08 g, 5.69 mmol) to give 1.04 g of the title compound as a yellow solid: mass spectrum (ion spray): m/z=432 (M+1); Analysis for C25H29N5S: calcd: C, 69.57; H, 6.77; N, 16.22; found: C, 69.40; H, 6.90; N, 15.98.

Sources & evidence

ORD record
ord-fcef50f3cc9d471fa388993cd43979ca
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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