HCID 21093530, compound → (S)-2-Isopropyl-10-{3-[2-(4-methoxy-phenyl)-ethyl]-piperazin-1-yl}-4H-3-thia-1,4,9-triaza-benzo[f]azulene

HRID 1350459Notes

Reaction equation

HRID 1350459 reaction equation
[CH:1]([C:4]1[S:13][C:12]2[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=[C:7]([NH2:18])[C:6]=2[N:5]=1)([CH3:3])[CH3:2].[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C@H:29]2[CH2:34]N[CH2:32][CH2:31][NH:30]2)=[CH:23][CH:22]=1>>[CH:1]([C:4]1[S:13][C:12]2[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=[C:7]([N:18]3[CH2:32][CH2:31][NH:30][C@@H:29]([CH2:28][CH2:27][C:24]4[CH:25]=[CH:26][C:21]([O:20][CH3:19])=[CH:22][CH:23]=4)[CH2:34]3)[C:6]=2[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 21093530HCID 21093530, compoundHCID 1357977402-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine

Product 1

HCID 136005625(S)-2-Isopropyl-10-{3-[2-(4-methoxy-phenyl)-ethyl]-piperazin-1-yl}-4H-3-thia-1,4,9-triaza-benzo[f]azuleneYield 38.4%

Procedure

By using a similar method of the method of Example 460, using 2-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine(1.48 g, 5.7 mmol) and (S)-2-[2-(4-methoxy-phenyl)-ethyl]-piperazine (1.26 g, 5.7 mmol) to give 1.01 g of the title compound as a yellow solid: mass spectrum (ion spray): m/z=462 (M+1); Analysis for C26H31N5OS(0.3 H2O): calcd: C, 66.87; H, 6.82; N, 15.00; found: C, 66.58; H, 6.35; N, 14.96.

Sources & evidence

ORD record
ord-ff9dbfdab0a1452095e857d8496b3a70
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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